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Eosinophilic fasciitis

There is only one case report of eosinophilic fasciitis, co-incidentally from Ireland, as a cause of severe headache. Usually this condition affects the extremities.

This condition underlines to need to palpate the head in clinical examination of headache conditions - local tenderness may indicate a subcutaneous disorder of this sort. A biopsy is needed to confirm the diagnosis of this very, very rare disorder.

Eosinophils are white blood cells than stain positive with eosin stain and are active in immunological mediated disease and fighting parasitic diseases.

Eosinophilis are seen in this microscopic picture of blood cells - the large cells stain for eosin, and the granular inclusions are rich in enzymes such as histaminase and peroxidase. (Creative Commons License, courtesy of Taipei Veterans Hospital)

References

Nutman TB. Evaluation and differential diagnosis of marked, persistent eosinophilia.Immunology Allergy Clinics of North America. 2007; 27(3): 529-549. (Free Full text)

McGuigan C et al. Case report: recurrent temporalis muscle swelling and headache.Neurology. 2003;60(4):724-5.

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