Gabapentin

Many severe headache disorders can be treated:

1. Migraine - a randomised trial was done in 1998, but never published in full (to my knowledge), 145 subjects, dose 2400-3000mg/day
2. Chronic Daily Headache - 9% reduction in pain, randomised trial 2003, 133 subjects
3. Cluster Headache - case series only, but 8 out of 8 resistant cases became pain free, but there is better evidence for other medicines in cluster headche, such as verapamil
4. SUNCT - Several case series. One series of 3 cases all responded. Another 10 did not. Not certain to say if effective.
5. Trigeminal Neuralgia. Case series evidence only. Seemed to help at least one case of Multiple Sclerosis related neuralgia. NO randomised trials
6. Supraorbital Neuralgia. Case report only.
7. Glossopharyngeal neuralgia. Case series only. Recent series of 9 from Spain (article in Spanish, abstract in English 7/9 some response).
8. Occipital Neuralgia - Case report only.
9. High Altitude Headache - Case report only.
10. Hypnic Headache - Case report only
11. Nummular Headache

References

Mathew NT 1998 - presented to American Pain Society, California

Leandri M et al. Drug-resistant cluster headache: a pilot study Cephalalgia 2001;21:744-746 (Free Abstract only)

MC França Jr et al. Gabapentin-responsive idiopathic stabbing headache. Cephalalgia 2004;24:993-6 (Free Abstract only)

Cohen AS et al. Abnormal blink reflex studies in a patient with supraorbital neuralgia. Cephalalgia 2006;26:875-8. (Free Abstract only)

Moretti R et al. Glossopharyngeal neuralgia: a follow-up of four years of a single case.Eur J Pain. 2002;6:403-7. (Free Abstract only)

Frese A et al. Geniculate neuralgia as a manifestation of neuroborreliosis. Headache 2002;42:826-8(Free Abstract only) i.e. describes nervus intermedius pain treated with GBP.

Jafarian S et al. Low-dose-gabapentin in treatment of high-altitude headache. Cephalalgia 2007;27:1274-7 (Free Abstract only)



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