Tolfenamic AcidTolfenamic Acid (TA) has been tested in migraine, and is one of the few drugs tested for hangover headache in a scientific way. Dr Kiavola and colleagues asked 30 volunteers to take TA 200mg prior to a bout of drinking, and another 200mg after finishing drinking but before retiring to bed. On a separate occasion, the volunteers were given a dummy drug or placebo. The volunteers and the researchers did not know until after data were collected whether they had active drug or placebo (called double-blind testing). The results showed a highly significant reduction in hangover headache when volunteers were taking active drug compared to when they too placebo. There was also a positive effect on nausea, vomiting thirst and irritation. TA is also a recommended treatment for an acute migraine attack, after positive results in a study of 141 people published in 1998.
ReferencesKaivola S. Hangover headache and prostaglandins. Cephalalgia 1983;3:31-6 (Free Abstract only) - Probably the only proper randomised trial of a medical hangover treatment - they used TA.Myllylä VV et al. Headache 1998;38:201-7. - This was a randomised controlled trial comparing TA to Sumatriptan in migraine attacks of 141 people. (Free Abstract only)
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