Unilateral Headache - causes of pain which only ever happens on the same side of the head.Unilateral Headache means that the pain only ever occurs on one side of the head, and never shifts to the other. About one in five people with migraine will experienced "side-locked" pains in the head. However, a one-sided headache, which never moves, can suggest an underlying structural problem, not just simple migraine or tension-type headache. Here's the list of causes of "side-locked headache" - pain only ever on one side of the head: 
If you only ever have your headache return to the same side again and again and again - this is unusual, unless you have definite migraine. If the diagnosis is migraine, then this is not going to be a major concern, the risk of an underlying structural problem in migraine is tiny, and you should be assured that one in 5 people with migraine have side-locked headache attacks. If you do not have migraine and experience strictly one-sided headaches, a search for an underlying structural problem within the head, with CT Brain scan or MRI scan is indicated. The regions of interest are the areas either side of the pituitary gland (the parasellar structures, like the cavernous sinus), and the hypothalamus and pituitary itself. This is particularly true if your headache has reddening of the eye (conjunctival injection), eye watering (lacrimation), nasal blockage or eyelid drooping (ptosis) associated with it - the so called autonomic features.
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